| Actor | Character | Seasons | ||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | ||||
| Luke Benward | Jayden Hebberd | Main | ||||||
| Tyler Blackburn | Teddy Cruz | Main | ||||||
| Scott Clifton | John Weiner | Main | Guest | |||||
| Chris Colfer | Kurt Hummel | Recurring | Main | |||||
| Kaley Cuoco | Bella James | Main | ||||||
| Emilie De Ravin | Hallie Grace | Main | ||||||
| Kat Dennings | Nicole Martin | Main | ||||||
| Nina Dobrev | Honey Berry | Main | ||||||
| Zac Efron | Joshua Bennett | Main | ||||||
| Andrew Garfield | Chuck Salvatore | Recurring | Main | |||||
| Lucy Hale | Ana Watson | Recurring | Main | |||||
| Nicholas Hoult | James Holland | Main | ||||||
| Josh Hutcherson | Miles Larson | Main | ||||||
| Alex Jenkins | Ryder McDaniel | Main | ||||||
| Avan Jogia | Kevin Rhodes | Main | ||||||
| Joe Jonas | Aldy Williams | Recurring | Main | |||||
| Jennifer Lawrence | Monique Ducasse | Recurring | Main | |||||
| Logan Lerman | Adam Gray | Recurring | Main | |||||
| Landon Liboiron | Evan Marx | Main | ||||||
| Demi Lovato | Etta Amato | Main | ||||||
| Kate Mara | Natasha Leonard | Recurring | Main | |||||
| Leighton Meester | India Wilson | Main | Guest | |||||
| Ellen Page | Lana Addison | Main | ||||||
| Gwyneth Paltrow | Holly Holliday | Main | ||||||
| Walter Perez | Lucas Aguirre | Main | ||||||
| Naya Rivera | Santana Lopez | Recurring | Main | |||||
| Emmy Rossum | Breezy Hollister | Main | ||||||
| Christian Serratos | Natalia Jensen | Main | ||||||
| Emma Stone | Rose Mitchell | Main | ||||||
| Jeremy Sumpter | McKenzie Kenton | Recurring | Main | |||||
| Raven Symone | Deandra Hallifax | Main | ||||||
| Scout Taylor-Compton | Davies Dawson | Recurring | Main | |||||
| Max Thieriot | Jaxon Pierce | Main | ||||||
| Lucas Till | Riley Cabrera | Main | ||||||
| Ashley Tisdale | Taylor Atkinson | Recurring | Main | |||||
| Nico Tortorella | Dexter Iver | Main | ||||||
| Ashley Tisdale | Taylor Atkinson | Recurring | Main | |||||
| Paul Wesley | Reece Montgomery | Recurring | Main | |||||
| Kiely Williams | Kimberly Williams | Main | ||||||
| Rebel Wilson | Tess McCord | Main | ||||||